pksensi implements the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in physiologically based kinetic (PK) models, especially the physiologically based pharmacokinetic/toxicokinetic model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters.
Through pksensi, you can:
You can install the package via CRAN or GitHub:
Hsieh NH, Reisfeld B, Bois FY, Chiu WA. Applying a global sensitivity analysis workflow to improve the computational efficiencies in physiologically-based pharmacokinetic modeling. Frontiers in Pharmacology 2018 Jun; 9:588.
Hsieh NH, Reisfeld B, Chiu WA. pksensi: an R package to apply sensitivity analysis in pharmacokinetic modeling. 58th SOT Annual Meeting, Baltimore, USA, March 10–14, 2019.