pksensi implements the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in pharmacokinetic (PK) models, especially the physiologically based pharmacokinetic (PBPK) model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters.
Through pksensi, you can:
You can install the package via CRAN or GitHub:
# To get pksensi from CRAN (current version 1.0.0): install.packages("pksensi") # Or get the the development version from GitHub: if (!require("devtools")) install.packages("devtools") devtools::install_github("nanhung/pksensi")
This package includes a function that can help you install GNU MCsim more easily through the function
Hsieh NH, Reisfeld B, Bois FY, Chiu WA. Applying a global sensitivity analysis workflow to improve the computational efficiencies in physiologically-based pharmacokinetic modeling. Frontiers in Pharmacology 2018 Jun; 9:588.